The FDA recommended (January, 2006) that two drugs used for eczema, Elidel cream and Protopic ointment have black box warnings placed on their labels. A black box warning is the FDA’s most serious warning and the drugs will be recommended only after other prescription medication has been tried. Between October, 2005 and January, 2006 the FDA received 78 reports cancers (including lymphoma and skin cancer) developing in patients who used the drugs. Animal tests have shown an increase in cancer associated with the drugs,