A study involving over 4700 subjects published in Cancer Epidemiology Biomarkers & Prevention (January 1, 2008, Volume 17) looked at vitamin B6 intake and the incidence of colorectal cancer. The study found that there was an inverse, dose-depended association between vitamin B6 intake and the incidence of the disease. A high vitamin B6 intake can reduce the risk of the disease by 19%. In the Journal of Nutrition (Volume 137, Sept. 2007) research was published that showed a moderate deficiency of riboflavin (B2), folic acid, B6 and B12 may increase the risk of damage to the DNA, thus increasing the risk of colon cancer.