Research published in the Archives of Internal Medicine (2007; 167:188–194) found an association between the use of selective serotonin reuptake inhibitors (SSRIs)—commonly prescribed antidepressants such as Prozac—and an increased risk of fractures.
The study followed more than 5,000 adults over the age of 50 for five years. Researchers observed increased bone demineralization among SSRI users, along with a higher risk of falls. Overall, individuals taking these medications had approximately a two-fold increase in the risk of experiencing a clinical fragility fracture.
