Vitamin C Levels and Inflammatory Bowel Disease

Vitamin C plays an essential antioxidant role in protecting cells from oxidative stress. Research published in Free Radical Research (1995;22(2):131–143) found that individuals with inflammatory bowel disease (IBD)—including Crohn’s disease and ulcerative colitis—have significantly reduced vitamin C levels in the intestinal lining.

According to the study:

  • Crohn’s disease patients had vitamin C levels 35% below normal.

  • Ulcerative colitis patients had levels 73% below normal.

The authors reported that this depletion is largely due to oxidative stress generated by inflammatory cells. As a result, the epithelial cells lining the intestines become more susceptible to further oxidative damage.