A study published in the Headache (2005; 45(3):196–203) examined the use of butterbur extract in 108 children between the ages of six and 17 who experienced recurrent headaches.

Participants received daily supplementation with butterbur extract for four months and recorded headache frequency and severity in a headache diary. Among those receiving the butterbur extract, 77% reported a reduction in migraine frequency of 50% or greater. By the end of the study, 90% of participants reported an overall improvement in their headache symptoms.