A small, double-blind, placebo-controlled study published in Gynecologic and Obstetric Investigation (2007;64[4]:204–207) examined the effect of vitamin E supplementation on menopausal hot flashes.
The study included 51 menopausal women. Participants initially received a placebo for four weeks, followed—after a one-week interval—by supplementation with 400 IU of vitamin E per day for an additional four weeks. The frequency of hot flashes was recorded during both phases of the study.
The researchers observed a statistically significant reduction in the number of hot flashes during the vitamin E supplementation period compared with the placebo phase. Based on these findings, the authors concluded that vitamin E may have a modest beneficial effect on menopausal hot flashes.
