Pain? There Are Solutions Better Than Drugs

There are things you can do to get pain under control—and they don’t involve drugs! All drugs have side effects and often make matters worse.

  1. NSAIDs, the drugs commonly used for pain, cause more problems than they solve. Taking them for a couple of days is alright. Regular use, however, causes ulcers, irritation of the GI tract, tissue destruction (they destroy cartilage—making them a very BAD idea to use for arthritis). They have been linked to heart failure, kidney failure, and high blood pressure. Over time, they increase inflammation, which is why they become less effective the more you use them1,2,3,4,5,6,7,8,9,10,11.
  2. Diet can either increase inflammation, or it can decrease inflammation. Brightly colored produce, nuts, and seeds all contain substances (polyphenols and carotenoids) that fight inflammation12,13,14,15,16,17,18,19,20,21,22. Chemical additives, sugar, grains, and animal fat all increase inflammation. You don’t need to be vegan, but 75% of your diet should be fresh produce.
  3. Pancreatic enzymes can reduce inflammation. When taken with food, they help digestion. Many studies show that they reduce pain and inflammation when taken on an empty stomach, and often out-perform drugs23,24,25,26,27,28,29,30,31,32.
  4. Chiropractors excel at getting pain under control without drugs–especially when there is a mechanical cause. People think of chiropractors as “bone” doctors–they are really doctors of the nervous system.

A Simple Strategy for Pain Control

  1. Roadmap to Health Diet: This diet will reduce inflammation. We have menu plans and recipes for you. Click here to see the diet.
  2. Pancreatic Enzymes: Take 2, 2x/ on an empty stomach. The brand you choose should have 25 mg of chymotrypsin, according to Dr. Harry Eidenier (he’s right). 8x Pancreatin from Zorex fills the bill, but they will not sell to you. They sell only to physicians (another reason to find a health care practitioner to help you). Do not despair–other natural substances have been shown to reduce inflammation. See “Natural Substances for Pain” below.
  3. Find a good chiropractor.

Natural Substances for Pain

  • Curcumin has been extensively studied [33-44] and is a powerful natural anti-inflammatory.
  • MSM has also been well studied [45-54] reduces inflammation and is especially good for people with arthritis.
  • Omega-3 fatty acids have also been shown to reduce inflammation [46-48].

This is not the entire list. These supplements are included to give you some viable options.

Selected References

  1. (Pol Arch Med Wewn 2014;124(11):628-34). Our prescription drugs kill us in large numbers
  2. Archives of Internal Medicine October 28, 2002;162:2204-2208. Frequency of analgesic use and risk of hypertension in younger women
  3. New England Journal of Medicine December 20, 2001;345:1801-1808. Acetaminophen, Aspirin, and Chronic Renal Failure
  4. Archives of Internal Medicine (February 11, 2002;162:265-270). Association of Nonsteroidal Anti-inflammatory Drugs With First Occurrence of Heart Failure and With Relapsing Heart Failure
  5. Arch Intern Med. 1996 Jul 22;156(14):1530-6. Gastrointestinal tract complications of nonsteroidal anti-inflammatory drug treatment in rheumatoid arthritis. A prospective observational cohort study
  6. Journal of Bone and Mineral Research (June, 2002 17:963). Cyclo-oxygenase 2 function is essential for bone fracture healing
  7. Am J Gastroenterol. 2000 Jan;95(1):157-65. Risk factors for irritable bowel syndrome: role of analgesics and food sensitivities
  8. Am J Med . 2009 Sep;122(9):836-42. Do NSAIDs affect longitudinal changes in knee cartilage volume and knee cartilage defects in older adults?
  9. Biochem Pharmacol 1991 May 1;41(9):1375-84. Comparison of the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on proteoglycan synthesis by articular cartilage explant and chondrocyte monolayer cultures
  10. Br J Rheumatol . 1992;31 Suppl 1:13-7. Effect of non-steroidal anti-inflammatory drugs (NSAIDS) on glycosyltransferase activity from human osteoarthritic cartilage
  11. Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2637-43 T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans
  12. Br J Nutr. 2011 Sep;106(6):913-22 Strawberry anthocyanin and its association with postprandial inflammation and insulin
  13. J Nutr. 2015 Jul;145(7):1459-63. Supplementation of the Pure Flavonoids Epicatechin and Quercetin Affects Some Biomarkers of Endothelial Dysfunction and Inflammation in (Pre)Hypertensive Adults: A Randomized Double-Blind, Placebo-Controlled, Crossover Trial
  14. Food Chem. 2020 Apr 25;310:125797 Anthocyanin-rich extract from purple potatoes decreases postprandial glycemic response and affects inflammation markers in healthy men
  15. Nutr Rev. 2019 Jun 22:nuz018 Impact of anthocyanin-rich whole fruit consumption on exercise-induced oxidative stress and inflammation: a systematic review and meta-analysis
  16. Int J Mol Sci. 2018 Mar 12;19(3):816. Anthocyanin-Rich Extract from Red Chinese Cabbage Alleviates Vascular Inflammation in Endothelial Cells and Apo E -/- Mice
  17. PLoS One. 2018 Apr 11;13(4):e0195502 The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity
  18. Nutr Diabetes. 2017 May 15;7(5):e276 Flavonoid intake is inversely associated with obesity and C-reactive protein, a marker for inflammation, in US adults
  19. J Ethnopharmacol. 2013 Aug 26;149(1):169-75 The root barks of Morus alba and the flavonoid constituents inhibit airway inflammation
  20. Nutr Res. 2018 Apr;52:98-104 A diet high in carotenoid-rich vegetables and fruits favorably impacts inflammation status by increasing plasma concentrations of IFN-α2 and decreasing MIP-1β and TNF-α in healthy individuals during a controlled feeding trial
  21. Br J Nutr. 2014 Oct 28;112(8):1341-52 Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk
  22. J Perinatol. 2012 Jun;32(6):418-24 Cerebrospinal fluid levels of inflammation, oxidative stress and NAD+ are linked to differences in plasma carotenoid concentrations
  23. Antibiot Khimioter. 2012;57(9-10):25-7, 29-31 [Impact of exogenous proteolytic enzymes on immunogenesis in patients with urogenital infections]
  24. Br J Obstet Gynaecol. 1983 Jul;90(7):650-3 Polyglycolic acid and catgut sutures, with and without oral proteolytic enzymes, in the healing of episiotomies
  25. Aesthetic Plast Surg. Jan-Feb 1999;23(1):41-4. Orally administered proteases in aesthetic surgery
  26. 1993 Dec;42(12):856-61 [Perioperative enzyme therapy. A significant supplement to postoperative pain therapy?]
  27. Wien Med Wochenschr. 1996;146(5):91-5 [Results of a double-blind, randomized comparative study of Wobenzym-placebo in patients with cervical syndrome]
  28. Wien Med Wochenschr. 1996;146(3):55-8. [Drug therapy of activated arthrosis. On the effectiveness of an enzyme mixture versus diclofenac]
  29. Wien Med Wochenschr. 1999;149(21-22):577-80. [Reducing pain by oral enzyme therapy in rheumatic diseases]
  30. Adv Ther 2018 Jan;35(1):31-42. The Role of Trypsin:Chymotrypsin in Tissue Repair
  31. Journal of Strength and Conditioning Research (2007 Aug;21(3):661-7)
  32. Clinical Experimental Rheumatology (2006 Jan-Feb;24(1):25-30) Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs
  33. Arthritis & Rheumatism (2006; 54 (11):3452-3464) Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis
  34. Clinical Interventions in Aging (2014 ;9:451-8. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study
  35. Front Immunol. 2023 May 31:14:1121655. Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis
  36. 2024 Jul 26;16(15):2441. The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
  37. Complement Med Res. 2020;27(4):272-281 Curcumin Preparations Can Improve Flow-Mediated Dilation and Endothelial Function: A Meta-Analysis
  38. Phytother Res. 2022 Jan;36(1):85-97. Effect of curcumin on C-reactive protein as a biomarker of systemic inflammation: An updated meta-analysis of randomized controlled trials
  39. 2024 Jul:129:155619. Cardioprotective effects of curcumin against Diabetic Cardiomyopathies: A systematic review and meta-analysis of preclinical studies
  40. 2023 Apr:164:156144. Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials
  41. Front Immunol. 2022 Aug 1:13:896476. Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A Systematic Review and Meta-Analysis of 31 Randomized Controlled Trials
  42. Expert Rev Gastroenterol Hepatol. 2020 Dec;14(12):1171-1179. Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis
  43. Front Endocrinol (Lausanne). 2022 Oct 27:13:1051111. Therapeutic effect and safety of curcumin in women with PCOS: A systematic review and meta-analysis
  44. [1] Freedom Press; 2003. Msm-the Definitive Guide: A Comprehensive Review of the Science and Therapeutics of Methylsulfonylmethane.

    [2] U.S. Patent. August 30, 1979. Methylsulfonylmethane and Methods of Use.

    [3] PLoS One. 2016;11:e0159891. Methylsulfonylmethane inhibits RANKL-induced osteoclastogenesis in BMMs by suppressing NF-κB and STAT3 activities.

    [4] Biol Pharm Bull. 2009;32:651-656. The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages.

    [5] Cytokine. 2015;71:223-231. Methylsulfonylmethane inhibits NLRP3 inflammasome activation.

    [6] Osteoarthritis Cartilage. 2007;15:C123. The effect of distilled methylsulfonylmethane (MSM) on human chondrocytes in vitro.

    [7] Biol Pharm Bull. 2009;32:651-656. The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages.

    [8] Curr Vasc Pharmacol. 2012;10:4-18. The role of nitric oxide on endothelial function.

    [9] Clin Exp Immunol. 2002;129:4-10. A regulator of mast cell activation and mast cell-mediated inflammation.

    [10] U.S. Patent. July 26, 1989. Use of Methylsulfonylmethane to Relieve Pain and Relieve Pain and Nocturnal Cramps and to Reduce Stress-Induced Deaths in Animals.

    [11] U.S. Patent. June 26, 1986. Dietary Products and Uses Comprising Methylsulfonylmethane.

    [12] U.S. Patent. September 14, 1982. Dietary and Pharmaceutical Uses of Methylsulfonylmethane and Compositions Comprising It.

    [13] J Lab Clin Med. 1987;110:91-96. Effects of dimethyl sulfoxide on the oxidative function of human neutrophils.

    [14] Jpn Pharmacol Ther. 2004;32:421-428. Suppressive effect of methylsulfonylmethane (MSM) on type II collagen-induced arthritis in DBA/1J mice.

    [15] FASEB J. 2008;22:1094.3. Assessment of methylsulfonylmethane (MSM) on the development of osteoarthritis (OA): An animal study.

    [16] Toxicol Ind Health. 2013;29:187-201. The effectiveness of echinacea extract or composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model.

    [17] Cytokine. 2015;71:223-231. Methylsulfonylmethane inhibits NLRP3 inflammasome activation.

    [18] Osteoarthritis Cartilage. 2007;15:C123. The effect of distilled methylsulfonylmethane (MSM) on human chondrocytes in vitro.

    [19] J Bone Miner Metab. 2013;31:16-25. Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model.

    [20] PLoS One. 2015;10:e0141565. Methyl sulfone blocked multiple hypoxia- and non-hypoxia-induced metastatic targets in breast cancer cells and melanoma cells.

    [21] BMC Complement Altern Med. 2011;11:50. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: A randomized controlled study.

    [22] Osteoarthritis Cartilage. 2007;15:C231. The role of MSM in knee osteoarthritis: A double blind, randomized, prospective study.

    [23] Osteoarthritis Cartilage. 2006;14:286-294. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: A pilot clinical trial.

    [24] Int J Orthop. 2014;1:19-24. The effect of methylsulfonylmethane on osteoarthritic large joints and mobility.

    [25] Am J Transl Res. 2015;7:328. MSM ameliorates HIV-1 Tat induced neuronal oxidative stress via rebalance of the glutathione cycle.

    [26] Toxicol Appl Pharmacol. 2011;253:197-202. The effect of methylsulfonylmethane on the experimental colitis in the rat.

    [27] Inflammation. 2013;36:1111-1121. Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in mice.

    [28] Arch Pharm Res. 2013;36:1140-1148. Hepatoprotective effect of methylsulfonylmethane against carbon tetrachloride-induced acute liver injury in rats.

    [29] Iran J Basic Med Sci. 2013;16:896. Effect of methylsulfonylmethane pretreatment on acetaminophen-induced hepatotoxicity in rats.

    [30] Curr Ther Res. 2005;66:511-521. Open-label, randomized, controlled pilot study of the effects of a glucosamine complex on low back pain.

    [31] Acta Med Indones. 2017;49(2):105-111. Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial.

    [32] Life Sci. 1986;39:263-268. Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins.

    [33] J Sports Med Phys Fitness. 2012;52(2):170-174. Effect of methylsulfonylmethane supplementation on exercise – Induced muscle damage and total antioxidant capacity

    [34] J Pharm Pharmacol. 2011;63(10):1290-1294. Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men.

    [35] Acta Vet Scand. 2008;50(1):45. The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise.

    [36] Altern Med Rev. 2002;7:22-44. Sulfur in human nutrition and applications in medicine.

    [37] J Altern Complement Med. 2002;8:167-173. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis.

    [38] Burns. 2015;41:1775-1787. Topically applied metal chelator reduces thermal injury progression in a rat model of brass comb burn.

    [39] Dermatol Surg. 2006;32:526-531. Clinical and instrumental evaluation of skin improvement after treatment with a new 50% pyruvic acid peel.

    [40] Nat Med J. 2015;7. Effects of oral supplementation with methylsulfonylmethane on skin health and wrinkle reduction.

    [41] J Cosmet Dermatol. 2008;7:8-14. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: Clinical and instrumental evaluation.

    [42] PLoS One. 2012;7:e33361. Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways.

    [43] BMC Cancer. 2015;15:474. The combination of methylsulfonylmethane and tamoxifen inhibits the JAK2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts.

    [44] Chemotherapy. 2013;59:14-23. Methyl sulfone manifests anticancer activity in a metastatic murine breast cancer cell line and in human breast cancer tissue-part I: Murine 4T1 (66CL-4) cell line.

    [45] PLoS One. 2015;10:e0141565. Methyl sulfone blocked multiple hypoxia- and non-hypoxia-induced metastatic targets in breast cancer cells and melanoma cells.

    [46] Int J Oncol. 2016;48:836-842. Methylsulfonylmethane inhibits HER2 expression through STAT5b in breast cancer cells.

    [47] J Gastrointest Cancer. 2012;43:420-425. Cytotoxicity of methylsulfonylmethane on gastrointestinal (AGS, HEPG2, and KEYSE-30) cancer cell lines.

    [48] World J Hepatol. 2014;6:98-106. Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis.

    [49] Int J Oncol. 2014;44:883-895. Combination of AG490, a JAK2 inhibitor, and methylsulfonylmethane synergistically suppresses bladder tumor growth via the JAK2/STAT3 pathway.

    [50] PLoS One. 2015;10:e0141565. Methyl sulfone blocked multiple hypoxia- and non-hypoxia-induced metastatic targets in breast cancer cells and melanoma cells.

    [51] PLoS One. 2010;5:e11788. Methyl sulfone induces loss of metastatic properties and reemergence of normal phenotypes in a metastatic Cloudman S-91 (M3) murine melanoma cell line.

    [52] Chemotherapy. 2013;59:14-23. Methyl sulfone manifests anticancer activity in a metastatic murine breast cancer cell line and in human breast cancer tissue-part I: Murine 4T1 (66CL-4) cell line.

    [53] PLoS One. 2015;10:e0141565. Methyl sulfone blocked multiple hypoxia- and non-hypoxia-induced metastatic targets in breast cancer cells and melanoma cells.

    [54] PLoS One. 2010;5:e11788. Methyl sulfone induces loss of metastatic properties and reemergence of normal phenotypes in a metastatic Cloudman S-91 (M3) murine melanoma cell line.

  45. International Immunopharmacology Volume 111, October 2022, 109104 Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis