A randomized, double-blind, placebo-controlled trial published in Annals of the Rheumatic Diseases followed 60 patients with systemic lupus erythematosus for 24 weeks. Participants received either 3 g/day of omega-3 fatty acids or placebo. Disease activity was assessed using SLAM-R and BILAG scores, along with measures of endothelial function and oxidative stress.
Patients receiving omega-3 supplementation showed significant improvements in lupus disease activity scores and reductions in oxidative stress, along with improved endothelial function. The authors concluded that fish oil supplementation exerted a therapeutic, anti-inflammatory effect in patients with SLE.
