Editor’s Note: This article was originally published in 2018 and is preserved for historical interest. Some recommendations, regulations, and scientific evidence have changed since it was written. It reflects the research and perspectives available at that time.

A study involving over 4700 subjects published in Cancer Epidemiology Biomarkers & Prevention (January 1, 2008, Volume 17) looked at vitamin B6 intake and the incidence of colorectal cancer. The study found that there was an inverse, dose-depended association between vitamin B6 intake and the incidence of the disease. A high vitamin B6 intake can reduce the risk of the disease by 19%. In the Journal of Nutrition (Volume 137, Sept. 2007) research was published that showed a moderate deficiency of riboflavin (B2), folic acid, B6 and B12 may increase the risk of damage to the DNA, thus increasing the risk of colon cancer.