Folic acid is important for normal brain function and is present in cerebrospinal and extracellular fluids. Adequate folate status has been associated with mental and emotional well-being, reflecting its role in neurotransmitter synthesis and methylation pathways. Folate also supports normal liver function and participates in a wide range of metabolic processes.
The term folate shares its root with “foliage,” reflecting the presence of naturally occurring folate in fresh fruits and vegetables.
Emerging research suggests that folate status may also be relevant to allergic conditions. A study published in the Journal of Allergy and Clinical Immunology (June 2009; Volume 123, Issue 6:1253–1259.e2) examined the relationship between folate levels and markers of allergic disease.
Using data from the 2006 National Health and Nutrition Examination Survey (NHANES), researchers analyzed serum folate levels and total immunoglobulin E (IgE) concentrations—an antibody associated with allergic responses—in 8,083 individuals aged two years and older. Serum folate levels were inversely associated with total IgE concentrations. In addition, individuals with lower folate levels were more likely to report allergies, wheezing, or asthma.
