Participants were divided into two groups. Ten subjects received 10 mg of oral melatonin daily for two weeks, while the remaining ten served as controls and did not receive melatonin. Within five days, half of the subjects receiving melatonin experienced a reduction in headache frequency. In these individuals, headaches remained suppressed until melatonin supplementation was discontinued. No participants in the control group reported symptom relief.
A study published in Neurology (2004;63(4):757) evaluated melatonin for migraine prevention. Of the 34 subjects enrolled, 32 completed the study and received 3 mg of melatonin nightly. Among those completing the trial, 25 experienced at least a 50% reduction in headache frequency, and eight reported complete remission.
Together, these findings suggest that melatonin may influence headache patterns in some individuals, potentially through effects on circadian regulation. While both studies were small, they support further investigation into the role of melatonin in cluster and migraine headaches.
