A randomized, placebo-controlled study published in Nutrition (2012;28(3):250–255) examined the effects of CoQ10 supplementation in 40 patients with coronary artery disease. Participants were divided into three groups and received either 150 mg of CoQ10 per day, 60 mg of CoQ10 per day, or a placebo for 12 weeks.
At the end of the study, markers of inflammation and oxidative stress—including interleukin-6 (IL-6) and malondialdehyde—were significantly lower in the CoQ10-supplemented groups compared with placebo. Both CoQ10 groups showed increased plasma CoQ10 levels, and higher CoQ10 concentrations were inversely associated with inflammatory markers.
