A small study published in Headache (2006;46[5]:788–793) examined the effects of an antioxidant supplement in 12 patients with migraines who had not responded to standard treatments, including beta-blockers and serotonin (5-HT) receptor agonists.
Participants took a daily supplement for three months containing vitamin C (60 mg), vitamin E (30 IU), and pine bark extract (120 mg). Migraine severity and disability were assessed using the Migraine Disability Assessment (MIDAS) questionnaire before supplementation and again after three months.
After treatment, subjects showed a mean 50.6% improvement in MIDAS scores. Participants also reported fewer headache days and reduced headache severity.
