Research has shown that certain B vitamins—particularly vitamins B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin)—can help reduce pain. These vitamins appear to influence nociceptors, the specialized nerve endings that respond to tissue damage such as fractures, bruises, inflammation, burns, and other injuries.
Earlier experimental research, including work presented to the American Physiological Society in 2003, demonstrated that B vitamins can suppress sensory neurons in the spinal cord that are activated by nociceptors. More recent animal studies suggest that a combination of vitamins B1, B6, and B12 may also reduce neuropathic pain—pain caused by direct injury to the nervous system.
In these studies, mice given B vitamins showed a reduced pain response, measured by decreased paw withdrawal following heat stimulation. The degree of pain reduction closely followed the dose of B vitamins administered. Other research has similarly shown that B vitamins may help reduce pain associated with neuropathy.
It is also worth noting that diets high in refined sugar and refined carbohydrates—such as white bread and processed grains—can deplete B vitamins. Avoiding refined foods while recovering from pain or nerve irritation may help support normal nerve function and healing.
Other studies have shown that B vitamins can reduce the pain from neuropathy.
