Boron is a trace element that has been studied for potential effects on immune function and hormone metabolism. Experimental research in animal models has suggested that physiological amounts of dietary boron can influence immune-related markers, including changes in skinfold responses following antigen exposure and increases in circulating natural killer cells after immune stimulation. These findings have prompted investigation of boron in human populations.
A double-blind, crossover study published in the Journal of Trace Element Experimental Medicine (1999; 12:251–261) examined the effects of boron supplementation in 43 perimenopausal women experiencing symptoms associated with menopause. Participants received 2.5 mg of boron per day, administered as sodium borate, and placebo in two separate 90-day periods, with the order randomized.
The effects of boron supplementation on menopausal symptoms were variable. Twenty-one participants reported an increase in hot flashes and night sweats during the boron phase, while ten reported a reduction in symptoms. Fifteen women reported no noticeable change in symptoms with boron supplementation.
Despite the mixed symptom response, several physiological changes were observed. Boron supplementation was associated with an increase in white blood cell count, as well as increases in circulating levels of 17β-estradiol, alkaline phosphatase, and thyroxine. The authors noted that these findings suggested that boron may influence immune parameters and hormone metabolism, although the clinical significance of these changes remained unclear.
The study highlighted interindividual variability in response to boron supplementation and underscored the need for further research to clarify its biological effects and potential role in human health.
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