Editor’s Note: This article was originally published in 2018 and is preserved for historical interest. Some recommendations, regulations, and scientific evidence have changed since it was written. It reflects the research and perspectives available at that time.

A cross-sectional study appearing in the Journal of the American Dietetic Association (2009; 109(8): 1406-10) compared 100 patients hospitalized with heart failure to healthy controls. More of the heart failure patients (38%) were deficient in vitamin B6 than subjects in the control group (19%). Also more of the patients were riboflavin deficient (27%) than controls (2%). Taking supplements did not seem to ameliorate these differences.