A study published in the Journal of Agricultural and Food Chemistry (2006; 54(14): 5203–5207) examined the effects of apigenin in a mouse model of allergic inflammation. Apigenin is a flavonoid (a type of polyphenol)—a class of plant-derived antioxidants known for anti-inflammatory and anti-tumor properties. It is found in relatively high amounts in herbs such as parsley, thyme, and peppermint.
In the study, mice were divided into two groups: a control group and a group receiving apigenin in their diet for two weeks. Levels of immunoglobulin E (IgE), a marker commonly associated with allergic responses, were significantly lower in the apigenin-supplemented mice. In addition, several inflammatory cytokines involved in allergic reactions were reduced in the treated group.
These findings suggest that apigenin may help modulate immune and inflammatory responses associated with allergy, at least in this experimental model.
